Gail Siewiorek
Ph.D. (2010), Biomedical Engineering Department, Carnegie Mellon University
Hamburg Hall 1210
Email: gailms@andrew.cmu.edu
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Gail Siewiorek earned her B.S. in Biomedical Engineering with an emphasis on Biomechanics in Spring
2005 from Washington University in St. Louis. She immediately started graduate school at Carnegie Mellon in the Fall of 2005 and is
currently a PhD Candidate in Biomedical Engineering. Her PhD thesis involves experimental testing and design of cerebral protection
devices for carotid artery stenting. |
Project Description To address the problem of risk of embolization in carotid artery stenting (CAS), we are evaluating the carotid artery flow dynamics in the presence of cerebral protection within the context of assessing the design functionality of cerebral protection devices (CPDs) on the basis of computational and experimental methodologies. In particular, we intend to (i) assess CPD performance in vitro to derive a set of flow-induced variables that are influenced by specific device design characteristics and (ii) characterize carotid artery flow dynamics in the presence of cerebral protection. These objectives will be achieved by performing bench-top testing of CPDs under pulsatile flow conditions using a novel flow-loop apparatus and testing protocol based on a blood mimicking fluid and compliant patient-specific carotid artery flow models. The expected outcomes are the plaque emboli capture rates of CPDs and quantification of the simulated in vivo flow conditions that can lead to an elevated thrombosis potential. Additionally, design and optimization of CPDs will be performed by means of computational fluid dynamics of carotid artery flow with virtual deployment of devices at the internal carotid artery.
Emboshield embolic protection filter deployed in the internal carotid artery and filled with emboli.
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